On Patrol

Here we combine ideas from the HelloWorld.jl and LetsGetMoving.jl examples to simulate T-Cells patrolling through a dense layer of epithelial cells.

Start by loading in the CellularPotts.jl package and creating a space where cells can exist.

using CellularPotts
space = CellSpace(200,200)

200×200 Periodic 8-Neighbor CellSpace{2,Int64}

Initialize a new CellTable with 75 epithelial cells and 5 T-Cells

initialCellState = CellTable(
    [:Epithelial, :TCell],
    [500, 400],
    [75, 5]);

Note that for the MigrationPenalty we set the epithelial cell's scaling factor to zero. This effectively removes this penalty from the cell type.

penalties = [
    AdhesionPenalty([0 30 30;
                    30 30 30
                    30 30 30]),
    VolumePenalty([10,10]),
    MigrationPenalty(50, [0,50], size(space))
    ]

3-element Vector{Penalty}:
 AdhesionPenalty([0 30 30; 30 30 30; 30 30 30])
 VolumePenalty([0, 10, 10])
 MigrationPenalty(50, [0, 0, 50], sparse(Int64[], Int64[], Int64[], 200, 200))

Create a new CellPotts model.

cpm = CellPotts(space, initialCellState, penalties)

Cell Potts Model:
Grid: 200×200
Cell Counts: [Epithelial → 75] [TCell → 5] [Total → 80]
Model Penalties: Adhesion Migration Volume
Temperature: 20.0
Steps: 0

Record the simulation

recordCPM("OnPatrol.gif", cpm)

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